When macrocytic anemia is due to a problem with the bone marrow or an organ, this underlying cause can trigger further complications. For example, people with untreated bone marrow disorders may develop leukemia. Most cases of macrocytic anemia are due to vitamin deficiencies, which can cause different complications depending on the vitamin: Vitamin B-12 deficiencies A vitamin B-12 deficiency can cause:

• neural tube defects in babies born to mother  with a B-12 deficiency
• infertility
• mobility problems and tingling in the hands and feet
• memory loss

Folate deficiencies A folate deficiency can cause:

• infertility
• an increased risk of some cancers, including colon cancer.
• cardiovascular health problem
• an increased risk of a placenta rupture before or during childbirth

What is the treatment for macrocytic anemia?